| | TER - 13/03/2018 - LA OLLA AZULGRANA - 21:30 hs | | |
Grêmio | | x | | Monagas |
| | TER - 04/04/2018 - ARENA DO GRÊMIO - 19:15 hs | | |
Bolívar | | x | | Colo-Colo |
| | QUA - 14/03/2018 - HERNANDO SILES - 19:15 hs | | |
Atlético Nacional | | x | | Delfín |
| | QUA - 14/03/2018 - ATANASIO GIRARDOT - 21:45 hs | | |
Libertad | | x | | The Strongest |
| | SÁB - 03/03/2018 - NICOLÁS LEOZ - 19:15 hs | | |
Peñarol | | x | | Atlético Tucumán |
| | QUA - 04/04/2018 - CENTENARIO - 19:15 hs | | |
Emelec | | x | | Flamengo |
| | QUA - 14/03/2018 - GEORGE CAPWELL - 21:45 hs | | |
River Plate | | x | | Santa Fe |
| | QUI - 05/04/2018 - MONUMENTAL DE NÚÑEZ - 19:15 hs | | |
U. de Chile | | x | | Racing |
| | TER - 03/04/2018 - NACIONAL DE SANTIAGO - 21:30 hs | | |
Cruzeiro | | x | | Vasco |
| | QUA - 04/04/2018 - MINEIRÃO - 21:45 hs | | |
Estudiantes | | x | | Real Garcilaso |
| | QUA - 14/03/2018 - CIUDAD DE LA PLATA - 19:15 hs | | |
Santos | | x | | Nacional |
| | QUI - 15/03/2018 - - 19:15 hs | | |
Corinthians | | x | | Deportivo Lara |
| | QUA - 14/03/2018 - ARENA CORINTHIANS - 21:45 hs | | |
Independiente | | x | | Millonarios |
| | QUI - 15/03/2018 - AVELLANEDA - 21:30 hs | | |
Boca Juniors | | x | | Junior Barranquilla |
| | QUA - 04/04/2018 - LA BOMBONERA - 21:45 hs | | |
Palmeiras | | x | | Alianza Lima |
| | TER - 03/04/2018 - ARENA PALMEIRAS - TBD | | |
